MovDisordV3, Main, Exploration, bibRecord, 002D78

Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease

Identifieur interne : 002D78 ( Main/Exploration ); précédent : 002D77; suivant : 002D79

Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease

Auteurs : Lindsy N. Williams [États-Unis] ; Paul Seignourel [États-Unis] ; Gregory P. Crucian [États-Unis] ; Michael S. Okun [États-Unis] ; Ramon L. Rodriguez [États-Unis] ; Frank M. Skidmore [États-Unis] ; Paul S. Foster [États-Unis] ; Charles E. Jacobson Iv [États-Unis] ; Janet Romrell [États-Unis] ; Dawn Bowers [États-Unis] ; Hubert H. Fernandez [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-01.

RBID : ISTEX:421E88E8B5E5AB517C9E5E69EDBDDC431764B9EC

Descripteurs français

Pascal (Inist)
- Cognition, Démence, Instabilité, Latéralité, Parkinson maladie, Système nerveux pathologie, Trouble cognition.

English descriptors

KwdEn :
- Aged, Cognition, Cognition Disorders (etiology), Cognitive disorder, Dementia, Disability Evaluation, Female, Functional Laterality (physiology), Humans, Instability, Laterality, Male, Mental Status Schedule, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson disease, Parkinson's disease, Severity of Illness Index, Statistics as Topic, bradykinesia, cognition, dementia, motor, postural instability.
MESH :
- complications : Parkinson Disease.
- etiology : Cognition Disorders.
- physiology : Functional Laterality.
- Aged, Disability Evaluation, Female, Humans, Male, Mental Status Schedule, Middle Aged, Severity of Illness Index, Statistics as Topic.

Abstract

We studied the relationship between two screening cognitive measures and off motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = −0.57, t(104) = −3.31, P < 0.01, and Dementia Rating Scale‐2 (DRS‐2), normalized β = −0.45, t(104) = −2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β = −0.39, t(105) = −3.19, P < 0.01, and DRS‐2 scores, normalized β = −0.40, t(106) = −3.28, P < 0.01. When including left‐sided and right‐sided subscores, only the right‐sided symptoms predicted DRS‐2 scores, normalized β = −0.28, t(105) = −2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized β = −0.22, t(105) = −1.95, P = 0.054. We therefore found that right‐sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function. © 2006 Movement Disorder Society

Url:

https://api.istex.fr/document/421E88E8B5E5AB517C9E5E69EDBDDC431764B9EC/fulltext/pdf

DOI: 10.1002/mds.21220

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">We studied the relationship between two screening cognitive measures and off motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = −0.57, t(104) = −3.31, P < 0.01, and Dementia Rating Scale‐2 (DRS‐2), normalized β = −0.45, t(104) = −2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β = −0.39, t(105) = −3.19, P < 0.01, and DRS‐2 scores, normalized β = −0.40, t(106) = −3.28, P < 0.01. When including left‐sided and right‐sided subscores, only the right‐sided symptoms predicted DRS‐2 scores, normalized β = −0.28, t(105) = −2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized β = −0.22, t(105) = −1.95, P = 0.054. We therefore found that right‐sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function. © 2006 Movement Disorder Society</div>
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Movement Disorders (revue)

Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease

Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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